A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora.

Erscheingsdatum 
August 2016
Autoren 
H Stettler, P Kurka, N Lunau, C Manger, A Böhling, S Bielfeldt, KP Wilhelm, S Dähnhardt-Pfeiffer, D Dähnhardt, FHH Brill, H Lenz
Bibliografische Daten 
The Journal of dermatological treatment, 2016 Aug 2:1-8. [Epub ahead of print], PMID: 27425824, DOI: 10.1080/09546634.2016.1214235
Abstract 

PURPOSE:

Two randomized, intra-individual comparison studies were performed in healthy subjects to evaluate the skin moisturization and barrier restoration potential of a new topical panthenol-containing emollient (NTP-CE) (Study 1), and its effect on skin microflora (Study 2).

METHODS:

In Study 1 (N = 23), two skin areas, one challenged with 0.5% sodium dodecyl sulfate (SDS) solution and one unchallenged, were treated with NTP-CE for 3 weeks. Transepidermal water loss (TEWL), skin hydration, and intercellular lipid lamellae (ICLL) organization were measured at regular intervals during the study. In Study 2 (N = 20), quantitative bacterial cultures were obtained over 6 h from a skin area undergoing wash stress with 10% SDS with subsequent single application of NTP-CE.

RESULTS:

In Study 1, mean AUC for TEWL reduction from baseline was more pronounced with NTP-CE compared with control (-168.36 vs. -123.38 g/m2/h, p = 0.023). NTP-CE use was also associated with statistically significant improvements in stratum corneum hydration and an increase in mean ICLL length from baseline (day 22: 120.61 vs. 35.85 nm/1000 nm2, p < 0.001). In Study 2, NTP-CE use had no negative impact on bacterial viability.

CONCLUSIONS:

NTP-CE use has favorable and lasting effects on barrier function and repair as well as skin hydration without negatively influencing bacterial viability.

KEYWORDS:

Emollient; microbiome; moisturization; panthenol; randomized controlled study; repair; skin; skin barrier; topical